Henderson I R, Navarro-Garcia F, Nataro J P
Dept of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA.
Trends Microbiol. 1998 Sep;6(9):370-8. doi: 10.1016/s0966-842x(98)01318-3.
The autotransporters, a family of secreted proteins from Gram-negative bacteria, possess an overall unifying structure comprising three functional domains: the amino-terminal leader sequence, the secreted mature protein (passenger domain) and a carboxy-terminal (beta-) domain that forms a beta-barrel pore to allow secretion of the passenger protein. Members of this family have been implicated as important or putative virulence factors in many Gram-negative pathogens.
自转运蛋白是革兰氏阴性菌分泌的一类蛋白质，具有一个统一的整体结构，由三个功能结构域组成：氨基末端前导序列、分泌的成熟蛋白（乘客结构域）和羧基末端（β-）结构域，后者形成一个β-桶状孔道，以允许乘客蛋白分泌。该家族成员在许多革兰氏阴性病原体中被认为是重要的或假定的毒力因子。
