Heinsoo M, Eelmäe J, Kuklane M, Tomberg T, Tikk A, Asser T
Department of Neurology and Neurosurgery, University of Tartu, Estonia.
Acta Neurochir Suppl. 1998;71:13-5. doi: 10.1007/978-3-7091-6475-4_4.
It is suggested that reduced intracranial compliance may be present even when measured ICP is normal and may precede clinical deterioration. Our findings reflect a decompensation of hydrodynamic parameters more pronounced 4-7 postictal days, when compliance is reduced not only in patients with poor clinical condition, but also in patients with Hunt-Hess grade I-III. Increased CSF outflow resistance in the first few days is not surprising; it is thought to be due to the blockage of flow of CSF through the basal subarachnoid cisterns and clogging of the arachnoid villi with erythrocytes and fibrin. Enlargement of ventricles seen on CT scan at the same time suggests the development of acute hydrocephalus. During the first days after SAH, our data reflects evidence of ventricular enlargement in patients presenting with both poor and better clinical condition. We conclude that the monitoring of ICP and dynamic measuring of CSF hydrodynamic parameters is important for longer than the generally accepted few days for selected cases after SAH.
有人认为,即使测量的颅内压正常,颅内顺应性也可能降低,且可能先于临床恶化出现。我们的研究结果表明,在发作后4 - 7天,流体动力学参数的失代偿更为明显,此时不仅临床状况较差的患者顺应性降低,Hunt - Hess分级为I - III级的患者顺应性也会降低。最初几天脑脊液流出阻力增加并不奇怪;据认为这是由于脑脊液通过基底蛛网膜下腔池的流动受阻以及红细胞和纤维蛋白堵塞蛛网膜绒毛所致。同时CT扫描显示脑室扩大提示急性脑积水的发生。在蛛网膜下腔出血后的最初几天,我们的数据反映出临床状况较差和较好的患者均有脑室扩大的迹象。我们得出结论,对于蛛网膜下腔出血后的特定病例,监测颅内压和动态测量脑脊液流体动力学参数的时间应比普遍接受的几天更长,这一点很重要。