干扰素对小鼠脾细胞合成IgE以致敏大鼠皮肤用于异种过继性皮肤过敏反应能力的抑制作用。
The suppressive effect of the interferon on the ability of mouse spleen cells synthesizing IgE to sensitize rat skin for heterologous adoptive cutaneous anaphylaxis.
作者信息
Ngan J, Lee S H, Kind L S
出版信息
J Immunol. 1976 Oct;117(4):1063-6.
PMID:977941
Abstract
Mouse spleen cells which are synthesizing IgE can sensitize rat skin for HACA. When such cells are treated with mouse interferon, their ability to sensitize rat skin is reduced or completely inhibited. Two hundred PRD50 units of interferon reduced HACA reactions by more than 50%; 600 units gave complete inhibition. Interferon may act by inhibiting IgE synthesis and/or release.
摘要
正在合成免疫球蛋白E（IgE）的小鼠脾细胞可使大鼠皮肤对同源抗半抗原抗体（HACA）产生致敏作用。当用小鼠干扰素处理这些细胞时，它们使大鼠皮肤致敏的能力会降低或完全被抑制。200个PRD50单位的干扰素可使HACA反应降低50%以上；600个单位则可完全抑制。干扰素可能通过抑制IgE的合成和/或释放起作用。
Zotero 插件