干扰素诱导的沙眼衣原体抑制作用：与抗病毒和抗增殖作用的解离
Interferon-induced inhibition of Chlamydia trachomatis: dissociation from antiviral and antiproliferative effects.
作者信息
de la Maza L M, Peterson E M, Goebel J M, Fennie C W, Czarniecki C W
出版信息
Infect Immun. 1985 Mar;47(3):719-22. doi: 10.1128/iai.47.3.719-722.1985.
Abstract
The yield of infectious Chlamydia trachomatis was analyzed in human (HeLa) and mouse (McCoy) cell lines treated with the human interferon (IFN) subtypes IFN-alpha A and IFN-alpha D, with their hybrids [IFN-alpha AD (BglII), IFN-alpha AD (PvuII), and IFN-alpha DA (BglII)] constructed in vitro from their expression plasmids, or with IFN-beta 1 or buffy coat IFN. In HeLa cells, a significant inhibition of Chlamydia infectivity was obtained with IFN-alpha D, IFN-alpha DA (BglII), and buffy coat IFN. In McCoy cells, IFN-alpha AD (BglII) and IFN-alpha AD (PvuII) induced a strong degree of inhibition of Chlamydia infectivity. In McCoy cells, there was a correlation among the antichlamydial, antiviral, and antiproliferative activities of the different IFNs tested. In HeLa cells, however, the ability of a particular IFN subtype to inhibit Chlamydia infectivity did not always correlate with its inhibitory effects on encephalomyocarditis virus replication or with its antiproliferative activity.
摘要
在用人干扰素（IFN）亚型IFN-αA和IFN-αD、由其表达质粒体外构建的杂交体[IFN-αAD（BglII）、IFN-αAD（PvuII）和IFN-αDA（BglII）]、IFN-β1或血沉棕黄层IFN处理的人（HeLa）和小鼠（McCoy）细胞系中，分析了感染性沙眼衣原体的产量。在HeLa细胞中，IFN-αD、IFN-αDA（BglII）和血沉棕黄层IFN对沙眼衣原体感染性有显著抑制作用。在McCoy细胞中，IFN-αAD（BglII）和IFN-αAD（PvuII）诱导了对沙眼衣原体感染性的高度抑制。在McCoy细胞中，所测试的不同IFN的抗衣原体、抗病毒和抗增殖活性之间存在相关性。然而，在HeLa细胞中，特定IFN亚型抑制沙眼衣原体感染性的能力并不总是与其对脑心肌炎病毒复制的抑制作用或其抗增殖活性相关。
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