Leenutaphong V, Sudtim S
Department of Dermatology Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Photodermatol Photoimmunol Photomed. 1998 Jun-Aug;14(3-4):112-5. doi: 10.1111/j.1600-0781.1998.tb00023.x.
The erythema efficacy of UVB irradiation from Philips TL12 and TL01 lamps has been evaluated and compared. Thirty-seven healthy Thai volunteers were irradiated on the previously unexposed lower back with TL12 and TL01 lamps in doses ranging 100 to 550 mJ/cm2 and 360 to 2020 mJ/cm2, respectively. Erythema was evaluated clinically and measured by a narrow-band spectrophotometer before exposure and 24 h after exposure. The threshold doses of UVB that induced barely perceptible erythema (MEDb) with well-defined border erythema (MEDw) and the steepness of the dose-response curves for erythema (DRAE) were compared. We found that MEDb and MEDw of the TL01 lamps were 4.19 and 4.52 times those of TL12 lamps, which were similar to those calculated from the CIE erythema action spectrum (4.2). However, the DRAE of the two lamps were quite similar. Because the initial dosage of UVB phototherapy is usually given as a percentage of a patient's MED, the initial exposure of TL01-UVB phototherapy should be about 4.2 times that of TL12-UVB.
已对飞利浦TL12和TL01灯管的UVB照射红斑疗效进行了评估和比较。37名健康的泰国志愿者以前未暴露的下背部分别接受了TL12和TL01灯管的照射，剂量范围分别为100至550 mJ/cm²和360至2020 mJ/cm²。在照射前和照射后24小时，通过临床评估红斑情况，并使用窄带分光光度计进行测量。比较了诱发刚刚可察觉的红斑（MEDb）、边界清晰的红斑（MEDw）的UVB阈值剂量以及红斑剂量反应曲线的斜率（DRAE）。我们发现，TL01灯管的MEDb和MEDw分别是TL12灯管的4.19倍和4.52倍，这与根据CIE红斑作用光谱计算得出的值（4.2）相似。然而，两种灯管的DRAE相当相似。由于UVB光疗的初始剂量通常以患者MED的百分比给出，因此TL01-UVB光疗的初始照射量应为TL12-UVB的约4.2倍。
