el-Ghorr A A, Norval M
Department of Medical Microbiology, University of Edinburgh Medical School, UK.
J Photochem Photobiol B. 1997 Apr;38(2-3):99-106. doi: 10.1016/s1011-1344(96)07454-4.
The narrow-band UVB (TL01) lamp (311 nm emission) was developed for use in phototherapy, as an alternative to a broad-band UVB source and to photochemotherapy, both of which have significant side effects and carry a risk of carcinogenesis. This new lamp has proved to be particularly effective at clearing psoriasis. It is now acknowledged that the TL01 lamp is probably 2-3 times more carcinogenic per minimum erythema dose than broad-band UVB, but the cumulative dose required in therapy is considerably less than when using broad-band UVB sources. In terms of irradiation dose, the TL01 lamp is about 5-10-fold less potent than broad-band UVB for erythema induction, hyperplasia, oedema, sunburn cell formation and Langerhans cell depletion from skin. However, the broad-band UVB to TL01 potency ratio for cis-urocanic acid formation in the skin is approximately unity. In addition, the TL01 lamp, as used in phototherapy, has relatively more suppressive effects than broad-band UVB on systemic immune responses as judged by natural killer cell activity, lymphoproliferation and cytokine responses. However, the TL01 lamp is less effective at reducing epidermal antigen presentation, inducing dendritic cell migration to lymph nodes draining irradiated sites and suppressing contact hypersensitivity at the doses tested. Therefore the use of the TL01 lamp in phototherapy should be considered carefully after weighing up its diverse effects on the skin and immune system.
窄谱中波紫外线（TL01）灯（发射波长311nm）被开发用于光疗，作为宽带中波紫外线光源和光化学疗法的替代方法，后两者都有显著的副作用且存在致癌风险。这种新灯已被证明在清除银屑病方面特别有效。现在人们认识到，TL01灯每最小红斑量的致癌性可能比宽带中波紫外线高2至3倍，但治疗所需的累积剂量远低于使用宽带中波紫外线光源时。就照射剂量而言，TL01灯在引起红斑、增生、水肿、晒伤细胞形成以及皮肤中朗格汉斯细胞耗竭方面的效力比宽带中波紫外线低约5至10倍。然而，在皮肤中形成顺式尿刊酸方面，宽带中波紫外线与TL01灯的效力比约为1。此外，从自然杀伤细胞活性、淋巴细胞增殖和细胞因子反应判断，光疗中使用的TL01灯对全身免疫反应的抑制作用相对比宽带中波紫外线更强。然而，在所测试的剂量下，TL01灯在减少表皮抗原呈递、诱导树突状细胞迁移至受照射部位引流的淋巴结以及抑制接触性超敏反应方面效果较差。因此，在权衡其对皮肤和免疫系统的多种影响后，应谨慎考虑在光疗中使用TL01灯。
