Farrar W E, O'dell N M
J Infect Dis. 1976 Sep;134(3):290-3. doi: 10.1093/infdis/134.3.290.
A strain of Chromobacterium violaceum isolated from a fatally infected patient was found to produce a beta-lactamase. When the organism was grown in drug-free medium, beta-lactamase activity was barely detectable, but when it was grown in the presence of penicillin G, a much larger amount of activity was produced. The beta lactamase was active primarily against cephalosporins; it was sensitive to inhibition by cloxacillin but resistant to p-chloromercuribenzoate. Thus this enzyme closely resembled the common type of beta-lactamase found in Pseudomonas aeruginosa. The organism was relatively susceptible to ticarcillin, carbenicillin, and cefoxitin, which resected hydrolysis by its beta-lactamase, but was quite resistant to 11 other beta-lactam antibiotics. Production of the beta-lactamase appeared to be mediated by chromosomal genes.
从一名因感染而死亡的患者体内分离出的一株紫色色杆菌被发现可产生一种β-内酰胺酶。当该菌在无药物培养基中生长时，几乎检测不到β-内酰胺酶活性，但当在青霉素G存在的情况下生长时，则会产生大量活性。该β-内酰胺酶主要对头孢菌素具有活性；它对氯唑西林的抑制敏感，但对对氯汞苯甲酸具有抗性。因此，这种酶与铜绿假单胞菌中常见类型的β-内酰胺酶非常相似。该菌对替卡西林、羧苄西林和头孢西丁相对敏感，这些药物可抵抗其β-内酰胺酶的水解作用，但对其他11种β-内酰胺抗生素具有相当的抗性。β-内酰胺酶的产生似乎由染色体基因介导。
