Sudol M
The Department of Biochemistry, Mount Sinai School of Medicine, New York, NY 10029, USA.
Oncogene. 1998 Sep 17;17(11 Reviews):1469-74. doi: 10.1038/sj.onc.1202182.
The study of oncogenes has illuminated many aspects of cellular signaling. The delineation and characterization of protein modules exemplified by Src Homology domains has revolutionized our understanding of the molecular events underlying signal transduction pathways. Several well characterized intracellular modules which mediate protein-protein interactions, namely SH2, SH3, PH, PTB, EH, PDZ, EVH1 and WW domains, are directly involved in the multitude of membrane, cytoplasmic and nuclear processes in multicellular and/or unicellular organisms. The modular character of these protein domains and their cognate motifs, the universality of their molecular function, their widespread occurrence, and the specificity as well as the degeneracy of their interactions have prompted us to propose the concept of the 'protein recognition code'. By a parallel analogy to the universal genetic code, we propose here that there will be a finite set of precise rules to govern and predict protein-protein interactions mediated by modules. Several rules of the 'protein recognition code' have already emerged.
癌基因的研究揭示了细胞信号传导的许多方面。以Src同源结构域为代表的蛋白质模块的描绘和表征，彻底改变了我们对信号转导途径潜在分子事件的理解。几个特征明确的介导蛋白质 - 蛋白质相互作用的细胞内模块，即SH2、SH3、PH、PTB、EH、PDZ、EVH1和WW结构域，直接参与多细胞和/或单细胞生物中的众多膜、细胞质和核过程。这些蛋白质结构域及其同源基序的模块化特征、它们分子功能的普遍性、它们的广泛存在以及它们相互作用的特异性和简并性，促使我们提出“蛋白质识别密码”的概念。通过与通用遗传密码的平行类比，我们在此提出，将有一组有限的精确规则来控制和预测由模块介导的蛋白质 - 蛋白质相互作用。“蛋白质识别密码”的几条规则已经出现。
