Dykhuizen M, Mitchen J L, Montefiori D C, Thomson J, Acker L, Lardy H, Pauza C D
Wisconsin Regional Primate Research Center, University of Wisconsin, Madison 53715, USA.
J Gen Virol. 1998 Oct;79 ( Pt 10):2461-7. doi: 10.1099/0022-1317-79-10-2461.
Clinical and laboratory markers of simian immunodeficiency virus (SIV) infection were studied during the first 3 months after intravenous inoculation of rhesus macaques. Virus-binding serum antibody titres were correlated strongly with disease progression (P < 0.005) and were predictive of disease outcome by 7 weeks after inoculation. Low virus-binding serum antibody responses to SIV occurred in animals that also showed acute depletion of circulating CD20+ B cells. Acute damage to the CD4+ T cell and CD20+ B cell populations rendered some animals incapable of mounting virus-specific antibody responses and these macaques became the rapidly progressing cases comprising approximately 20-30% of infected animal cohorts.
在恒河猴静脉接种后的前3个月内，对猴免疫缺陷病毒（SIV）感染的临床和实验室指标进行了研究。病毒结合血清抗体滴度与疾病进展密切相关（P < 0.005），并在接种后7周可预测疾病结果。对SIV的病毒结合血清抗体反应较低发生在那些同时出现循环CD20+B细胞急性耗竭的动物中。CD4+T细胞和CD20+B细胞群体的急性损伤使一些动物无法产生病毒特异性抗体反应，这些猕猴成为快速进展的病例，约占感染动物群体的20-30%。
