乙酰胆碱在大鼠松果体中的调节作用。

Modulatory role of acetylcholine in the rat pineal gland.

作者信息

Schenda J, Vollrath L

机构信息

Institute of Anatomy, University of Mainz, Germany.

出版信息

Neurosci Lett. 1998 Sep 18;254(1):13-6. doi: 10.1016/s0304-3940(98)00624-7.

DOI:10.1016/s0304-3940(98)00624-7

PMID:9780080

Abstract

The function of acetylcholine (ACh) in the mammalian pineal gland is unknown. To test the hypothesis that ACh exerts a modulatory role in this organ, in the present study electrophysiogical multiunit recordings were carried out in ex-vivo rat pineal glands superfused with different drugs. It was found that ACh (10(-7) M) as well as the cholinergic agonists oxotremorine (10(-7) M) and nicotine (10(-6) M) increased the discharge rates of most of the spontaneously active units and led to burst activity in previously regularly firing cells. It is concluded that ACh may play a modulatory role in the pineal by influencing the firing of a special population of pineal cells with perhaps receptor function.

摘要

乙酰胆碱（ACh）在哺乳动物松果体中的功能尚不清楚。为了验证ACh在该器官中发挥调节作用的假说，在本研究中，对用不同药物灌流的离体大鼠松果体进行了电生理多单位记录。结果发现，ACh（10⁻⁷ M）以及胆碱能激动剂氧化震颤素（10⁻⁷ M）和尼古丁（10⁻⁶ M）增加了大多数自发活动单位的放电率，并导致先前正常放电的细胞出现爆发性活动。得出的结论是，ACh可能通过影响一群可能具有受体功能的特殊松果体细胞的放电，在松果体中发挥调节作用。