Ylitalo P, Hepp R, Möhring J, Gross F
J Lab Clin Med. 1976 Nov;88(5):807-16.
In rats in which the renal mass had been reduced by 70 per cent, the effects of varying sodium intake on blood pressure, serum electrolytes, renin-angiotensin system, and some other parameters that were modified simultaneously were studied. Within 4 weeks, a high sodium diet (750 mEa. per kilogram) resulted in marked hypertension, whereas a standard sodium diet (150 mEq. per kilogram) elevated the blood pressure only slightly. A low sodium diet (less than 0.2 mEq. per kilogram) prevented the rise in blood pressure. In the hypertensive group, the hematocrit values were markedly decreased, indicating the expansion of extracellular and intravascular spaces. The compensatory renal hypertrophy was accelerated by the high sodium diet and retarded during restriction. During low sodium intake, the serum concentration of sodium was diminished and that of potassium elevated. During the high sodium diet, the sodium concentration was unchanged, but the potassium concentration was decreased. Subtotal nephrectomy diminished the plasma angiotensin II concentration, and the renin content of the kidney remnant was lower than that of the kidneys from control animals. Sodium restriction stimulated the renin angiotensin system markedly, whereas high sodium intake suppressed it. After subtotal nephrectomy, elevation of blood pressure, renal hypertrophy, and suppression of the renin-angiotensin system are closely related to sodium intake.
在肾质量减少了70%的大鼠中，研究了不同钠摄入量对血压、血清电解质、肾素 - 血管紧张素系统以及同时发生改变的其他一些参数的影响。在4周内，高钠饮食（每千克750毫当量）导致明显的高血压，而标准钠饮食（每千克150毫当量）仅使血压略有升高。低钠饮食（每千克低于0.2毫当量）可防止血压升高。在高血压组中，血细胞比容值明显降低，表明细胞外和血管内空间扩大。高钠饮食加速了代偿性肾肥大，而在限制钠摄入期间则使其减缓。在低钠摄入期间，血清钠浓度降低，钾浓度升高。在高钠饮食期间，钠浓度不变，但钾浓度降低。次全肾切除术后，血浆血管紧张素II浓度降低，残余肾脏的肾素含量低于对照动物的肾脏。钠限制显著刺激肾素 - 血管紧张素系统，而高钠摄入则抑制该系统。次全肾切除术后，血压升高、肾肥大和肾素 - 血管紧张素系统的抑制与钠摄入密切相关。
