Yamada K, Urisu A, Morita Y, Ando H, Wada E, Torii S, Goto M
Yamada Clinics, Fujita Health University School of Medicine.
Arerugi. 1998 Jul;47(7):687-93.
One hundred and ninety one subjects showing histories of immediate hypersensitive response to egg white ingestion and/or positive IgE antibody titers specific for egg white were enrolled in double-blind placebo-controlled oral challenge with freeze and dried, heated or heated and ovomucoid-depleted egg white antigens. Seventy seven were male and 114 female, and their ages ranged from 11 month to 10 years 5 month; 118 of them had atopic dermatitis, seven had asthma and 33 had both atopic dermatitis and bronchial asthma and 33 had urticaria. One hundred four children developed 147 positive symptoms including 131 immediate reactions and 16 non-immediate reactions by oral challenge tests. Respiratory symptoms were observed in 25 cases (17%) including cough alone in 12 cases (8.2%), and both wheezing and cough in 13 cases (8.8%). These were all observed as immediate reactions and accompanied with dermal symptoms. Frequency of respiratory symptoms correlated with specific IgE antibody titers for egg white. Heated and ovomucoid-depleted egg white was more hypoallergenic that heated or freeze and dried egg white with respect to respiratory symptoms as well as other symptoms. We concluded that respiratory symptoms were provoked through oral challenges with egg white in a part of egg-allergic children.
191名有摄入蛋清后立即出现过敏反应病史和/或蛋清特异性IgE抗体滴度呈阳性的受试者，参与了用冻干、加热或加热且去除类卵黏蛋白的蛋清抗原进行的双盲安慰剂对照口服激发试验。其中男性77名，女性114名，年龄范围从11个月至10岁5个月；其中118人患有特应性皮炎，7人患有哮喘，33人同时患有特应性皮炎和支气管哮喘，33人患有荨麻疹。104名儿童通过口服激发试验出现了147个阳性症状，包括131个速发反应和16个迟发反应。25例（17%）出现呼吸道症状，其中仅咳嗽12例（8.2%），喘息和咳嗽13例（8.8%）。这些均为速发反应，并伴有皮肤症状。呼吸道症状的发生率与蛋清特异性IgE抗体滴度相关。就呼吸道症状及其他症状而言，加热且去除类卵黏蛋白的蛋清比加热或冻干的蛋清致敏性更低。我们得出结论，一部分对鸡蛋过敏的儿童在口服蛋清激发试验后会引发呼吸道症状。
