Souza R L, Castro R M, Pereira L, Freund A A, Culpi L, Chautard-Freire-Maia E A
Department of Genetics, Federal University of Paraná, Curitiba, PR, Brazil.
Hum Biol. 1998 Oct;70(5):965-70.
The frequency of the butyrylcholinesterase K mutation was calculated on the basis of data obtained by polymerase chain reaction primer-introduced restriction analysis (PCR-PIRA). The population sample was composed of 177 Brazilians: 95 whites of predominantly European ancestry and 82 admixed individuals (European and African origin). The frequencies--18.4 +/- 2.8% for whites and 17.1 +/- 2.9% for admixed--did not differ from those previously obtained in North America, Scotland, Japan, and Denmark. The occurrence of the K mutation in Europeans, East Asians, and Africans suggests a relatively old origin for this mutation, and the similar frequencies found in these populations may suggest the operation of selective forces.
基于聚合酶链反应引物引入限制性分析（PCR-PIRA）获得的数据，计算丁酰胆碱酯酶K突变的频率。人群样本由177名巴西人组成：95名主要为欧洲血统的白人以及82名混血个体（欧洲和非洲血统）。白人的频率为18.4±2.8%，混血个体的频率为17.1±2.9%，这与之前在北美、苏格兰、日本和丹麦获得的频率没有差异。K突变在欧洲人、东亚人和非洲人中的出现表明该突变起源相对较早，并且在这些人群中发现的相似频率可能表明存在选择力的作用。
