Schonfeld W H, Eikin E P, Woltering E A, Modlin I M, Anthony L, Villa K F, Zagari M
Int J Technol Assess Health Care. 1998 Summer;14(3):514-25. doi: 10.1017/s0266462300011491.
Markov modeling was used to evaluate the cost-effectiveness of octreotide in treating carcinoid syndrome and VIPoma. For each condition, using octreotide was associated with doubled survival time. Octreotide was cost-effective for treating carcinoid tumor ($752 per additional year of life, two additional years on average), and cost saving for VIPoma.
马尔可夫模型用于评估奥曲肽治疗类癌综合征和血管活性肠肽瘤的成本效益。对于每种病症,使用奥曲肽可使生存时间翻倍。奥曲肽治疗类癌肿瘤具有成本效益(每增加一年生命成本为752美元,平均增加两年),且治疗血管活性肠肽瘤可节省成本。