Miura S, Fujimori H, Koseki S, Hokari R
Second Department of Internal Medicine, National Defense Medical College.
Nihon Rinsho. 1998 Sep;56(9):2228-34.
Gut-associated lymphoid tissue is the major inductive site of mucosal immune system, functionally independent of the systemic immune system. Particulate antigens are mainly uptaken from M cell of Peyer's patches, inducing IgA production in the intestinal mucosa. Lymphocytes are continuously recirculating through the intestinal mucosa to facilitate intestinal immune response. Dysregulation of lymphocyte migration and cytokine imbalance in the intestinal mucosa may be largely involved in the pathogenesis of inflammatory bowel diseases including intestinal allergy and Crohn's disease. There is also a possibility that dietary components especially long chain fatty acid could influence immune cell function of the intestinal mucosa. Because dietary components are closely associated with immunological function of intestinal mucosa, the importance of dietary manipulation for the management of inflammatory bowel diseases should be concerned.
肠道相关淋巴组织是黏膜免疫系统的主要诱导部位，在功能上独立于全身免疫系统。颗粒性抗原主要从派尔集合淋巴结的M细胞摄取，诱导肠道黏膜产生IgA。淋巴细胞持续通过肠道黏膜循环，以促进肠道免疫反应。肠道黏膜中淋巴细胞迁移失调和细胞因子失衡可能在很大程度上参与包括肠道过敏和克罗恩病在内的炎症性肠病的发病机制。饮食成分尤其是长链脂肪酸也有可能影响肠道黏膜的免疫细胞功能。由于饮食成分与肠道黏膜的免疫功能密切相关，因此应关注饮食调控在炎症性肠病管理中的重要性。
