Sawhney R C, Malhotra A S, Prasad R, Pal K, Kumar R, Bajaj A C
Department of Endocrinology and Metabolism, Defence Institute of Physiology and Allied Sciences, Delhi, India.
Int J Biometeorol. 1998 Aug;42(1):51-4. doi: 10.1007/s004840050083.
Plasma luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin (PRL) and testosterone levels were measured in nine eugonadal men in New Delhi and during the 1st week of different months of their stay at Dakshin Gangotri in Antarctica. During their 12-month stay in Antarctica, they were exposed to a severely cold climate, long polar nights and polar days, high wind velocity, increased amounts of solar and ultraviolet radiation and geomagnetism, as well as physical and social isolation. Plasma testosterone tended to increase in March, but a significant increase (P < 0.05) was not seen until April. The mean testosterone levels in May, June, September and November were also significantly higher than the March or New Delhi values. The absolute values of LH, FSH and PRL did not show any month-to-month changes in Antarctica. However, when the hormone levels were expressed as a percentage of the individual annual Antarctic mean, significant differences as a percentage of the individual annual Antarctic mean, significant differences were observed. The testosterone peak in April, May and June was associated with an increase in LH. The nadirs of testosterone, LH, FSH and PRL were seen in either July or August. FSH showed the highest values in March, whereas the highest PRL values were seen in November. These observations suggest the presence of circannual variations in gonadotropin, PRL and LH in Antarctica which are independent of polar days and polar nights. It appears that factors other than the duration of daylight might be involved in regulating these changes. The significance of maintenance of testosterone levels in the supra-physiological range in Antarctica remains unknown but may be important in acclimatization/habituation to the extreme polar cold by increasing basal metabolic rate, protein synthesis and erythropoiesis.
在新德里对9名性腺功能正常的男性进行了血浆促黄体生成素（LH）、促卵泡生成素（FSH）、催乳素（PRL）和睾酮水平的测量，并在他们于南极洲达欣冈戈特里停留的不同月份的第1周进行了复测。在他们在南极洲停留的12个月期间，他们暴露在严寒的气候、漫长的极夜和极昼、高风速、增加的太阳辐射和紫外线辐射以及地磁环境中，同时还面临身体和社交隔离。血浆睾酮在3月有升高趋势，但直到4月才出现显著升高（P<0.05）。5月、6月、9月和11月的平均睾酮水平也显著高于3月或新德里的水平。在南极洲，LH、FSH和PRL的绝对值没有显示出任何逐月变化。然而，当将激素水平表示为个体年度南极平均值的百分比时，观察到了显著差异。4月、5月和6月睾酮的峰值与LH的升高有关。睾酮、LH、FSH和PRL的最低点出现在7月或8月。FSH在3月显示出最高值，而PRL的最高值出现在11月。这些观察结果表明，在南极洲，促性腺激素、PRL和LH存在年周期变化，且与极昼和极夜无关。似乎除了日照时长之外的其他因素可能参与调节这些变化。在南极洲将睾酮水平维持在超生理范围内的意义尚不清楚，但可能通过增加基础代谢率、蛋白质合成和红细胞生成，对适应极端极地寒冷很重要。
