Youinou P, Amoura Z
Laboratoire d'immunologie, CHU, Brest.
Rev Prat. 1998 Mar 15;48(6):603-8.
Systemic lupus erythematosus is associated with a plethora of immunological abnormalities. First, there are antinuclear autoantibodies directed towards insoluble (mainly desoxyribonucleic acid, histones and nucleosomes) or soluble nuclear components (mainly Sm, RNP and Ro/SSA particles). There are then autoantibodies other than antinuclear, recognizing cells (erythrocytes, lymphocytes, neutrophils, endothelial cells), organelles (Golgi apparatus, ribosomes) or molecules (cardiolipids, C1q, stress proteins). Finally, there are immunological abnormalities other than autoantibodies, such as immune complexes, monoclonal immunoglobulins or complement variations. In fact the pathogenetic role of these perturbations remains a matter for speculation.
系统性红斑狼疮与多种免疫异常相关。首先，存在针对不溶性（主要是脱氧核糖核酸、组蛋白和核小体）或可溶性核成分（主要是Sm、RNP和Ro/SSA颗粒）的抗核自身抗体。其次，存在除抗核抗体之外的自身抗体，可识别细胞（红细胞、淋巴细胞、中性粒细胞、内皮细胞）、细胞器（高尔基体、核糖体）或分子（心磷脂、C1q、应激蛋白）。最后，存在除自身抗体之外的免疫异常，如免疫复合物、单克隆免疫球蛋白或补体变化。事实上，这些紊乱的致病作用仍有待推测。
