Ramadan H H, Owens R M, Tiu C, Wax M K
Department of Otolaryngology-Head and Neck Surgery, West Virginia University, Morgantown 26506-9200, USA.
Otolaryngol Head Neck Surg. 1998 Oct;119(4):381-4. doi: 10.1016/S0194-5998(98)70083-X.
The objective of this study was to determine whether maxillary sinus puncture caused an alteration in antibiotic treatment and thus affected the outcome of sinusitis in the intensive care unit.
A retrospective review was done of cases of maxillary sinus puncture between 1991 and 1994.
Forty-two patients were identified. All patients had findings suggestive of sinusitis on plain sinus films or CT scans of the sinuses. Twenty-five punctures (60%) recovered pus, of which 80% grew organisms. Fourteen patients (33%) had a negative lavage, and 12% of these samples grew organisms (p = 0.001). Sixty-eight percent of the cultures identified a single organism compared with 32% with multiple organisms. Gram-negative organisms were found most commonly, followed by anaerobes. In 57% of the cases antibiotic therapy was changed. In 77% of the cases the change was directed by the culture result and in 35% the therapy was changed despite a negative culture result (p = 0.002). Resolution of symptoms occurred in 83% of patients who had antibiotics changed whereas with no change in antibiotics only 42% had resolution (p = 0.001).
A sinus puncture seems to be helpful in patients with fever and positive findings on sinus films. If pus is obtained by maxillary puncture, a positive culture may be found in 80% of the cases. Changes in antibiotic regimen on the basis of culture findings seem to give a better outcome.
本研究的目的是确定上颌窦穿刺是否会导致抗生素治疗的改变,从而影响重症监护病房中鼻窦炎的治疗结果。
对1991年至1994年间上颌窦穿刺病例进行回顾性研究。
共确定42例患者。所有患者在鼻窦平片或鼻窦CT扫描上均有提示鼻窦炎的表现。25次穿刺(60%)抽出脓液,其中80%培养出微生物。14例患者(33%)灌洗结果为阴性,这些样本中有12%培养出微生物(p = 0.001)。68%的培养物鉴定出单一微生物,32%为多种微生物。最常发现革兰氏阴性菌,其次是厌氧菌。57%的病例抗生素治疗发生了改变。77%的病例改变是根据培养结果进行的,35%的病例尽管培养结果为阴性仍改变了治疗方案(p = 0.002)。抗生素治疗改变的患者中83%症状得到缓解,而未改变抗生素治疗的患者中只有42%症状得到缓解(p = 0.0)。
鼻窦穿刺似乎对发热且鼻窦片有阳性表现的患者有帮助。如果通过上颌窦穿刺获得脓液,80%的病例可能培养出阳性结果。根据培养结果改变抗生素治疗方案似乎能取得更好的治疗效果。