哮喘和支气管高反应性与XY长臂假常染色体区域相关。

Asthma and bronchial hyperresponsiveness linked to the XY long arm pseudoautosomal region.

作者信息

Holroyd K J, Martinati L C, Trabetti E, Scherpbier T, Eleff S M, Boner A L, Pignatti P F, Kiser M B, Dragwa C R, Hubbard F, Sullivan C D, Grasso L, Messler C J, Huang M, Hu Y, Nicolaides N C, Buetow K H, Levitt R C

机构信息

Magainin Institute of Molecular Medicine, Magainin Pharmaceuticals, Plymouth Meeting, Pennsylvania, 19462, USA.

出版信息

Genomics. 1998 Sep 1;52(2):233-5. doi: 10.1006/geno.1998.5445.

DOI:10.1006/geno.1998.5445

PMID:9782093

Abstract

We examined the long arm XY pseudoautosomal region for linkage to asthma, serum IgE, and bronchial hyperresponsiveness. In 57 Caucasian families multipoint nonparametric analyses provide evidence for linkage between DXYS154 and bronchial hyperresponsiveness (P = 0.000057) or asthma (P = 0.00065). This genomic region is approximately 320 kb in size and contains the interleukin-9 receptor gene. These results suggest that a gene controlling asthma and bronchial hyperresponsiveness maybe located in this region and that the interleukin-9 receptor is a potential candidate.

摘要

我们研究了XY染色体假常染色体区域长臂与哮喘、血清免疫球蛋白E及支气管高反应性之间的连锁关系。在57个白种人家庭中，多点非参数分析为DXYS154与支气管高反应性（P = 0.000057）或哮喘（P = 0.00065）之间的连锁提供了证据。该基因组区域大小约为320 kb，包含白细胞介素-9受体基因。这些结果提示，一个控制哮喘和支气管高反应性的基因可能位于该区域，且白细胞介素-9受体是一个潜在的候选基因。