Kulczykowska E
Marine Biology Center, Polish Academy of Sciences, 5 Saint Wojciech Street, 81 347 Gdynia, Poland.
Exp Physiol. 1998 Nov;83(6):809-20. doi: 10.1113/expphysiol.1998.sp004161.
The effects of exogenous arginine vasotocin (AVT), isotocin (IT) and melatonin on the blood pressure of conscious Atlantic cod (Gadus morhua) were examined. Ventral aortic blood pressure (PVA) was recorded from a cannula inserted into the afferent branchial artery of the third gill arch. Dorsal aortic blood pressure (PDA) was recorded via a cannula implanted into the efferent branchial artery in the same gill arch. Each fish received two doses (10 and 50 ng kg-1) of AVT, IT and melatonin. AVT was also administered in combination with melatonin. Injection of 10 ng kg-1 AVT produced significant hypertension, especially in animals injected during the daytime. In contrast, the same dose of IT induced no significant change in either PVA or PDA. Administration of 10 ng kg-1 melatonin at night caused a long-lasting decrease in both parameters. Melatonin also inhibited the increase in blood pressure elicited by AVT. These results indicate that AVT, but not IT, is vasopressor in the cod. The effects of combined administration of melatonin and AVT show the antihypertensive action of melatonin in AVT-induced hypertension.
研究了外源性精氨酸血管加压素（AVT）、异催产素（IT）和褪黑素对清醒大西洋鳕鱼（Gadus morhua）血压的影响。通过插入第三鳃弓传入鳃动脉的插管记录腹主动脉血压（PVA）。通过植入同一鳃弓传出鳃动脉的插管记录背主动脉血压（PDA）。每条鱼接受两剂（10和50 ng kg-1）的AVT、IT和褪黑素。AVT还与褪黑素联合给药。注射10 ng kg-1 AVT会导致显著的高血压，尤其是在白天注射的动物中。相比之下，相同剂量的IT对PVA或PDA均未引起显著变化。夜间给予10 ng kg-1褪黑素会导致这两个参数长期下降。褪黑素还抑制了AVT引起的血压升高。这些结果表明，在鳕鱼中，AVT具有血管升压作用，而IT没有。褪黑素与AVT联合给药的效果表明褪黑素对AVT诱导的高血压具有降压作用。
