Siffert J, Allen J C
Division of Pediatric Neurology, Department of Neurology, Beth Israel Medical Center, New York, N.Y., USA.
Pediatr Neurosurg. 1998 Jun;28(6):314-9. doi: 10.1159/000028669.
Surgical resection with or without radiation therapy confers long-term remission in approximately half of the patients newly diagnosed with ependymoma. Chemotherapy has a limited role in the management of ependymoma. In newly diagnosed infants, chemotherapy is utilized as an attempt to defer radiation. The use of chemotherapy in older children has provided no conclusive benefit. The largest experience with chemotherapy in ependymoma has been in children with recurrent disease. In this section, we will analyze the principal institutional and cooperative group phase I, phase II, and phase III clinical trials utilizing single-agent and multiagent chemotherapy in patients with recurrent ependymoma. In addition, future directions relating to novel medical oncologic therapies will also be discussed.
对于新诊断的室管膜瘤患者，手术切除联合或不联合放射治疗可使约一半患者获得长期缓解。化疗在室管膜瘤的治疗中作用有限。在新诊断的婴儿中，化疗被用作推迟放疗的一种尝试。在大龄儿童中使用化疗尚未显示出确凿的益处。化疗在室管膜瘤治疗方面的最大经验来自于复发性疾病的儿童患者。在本节中，我们将分析主要机构和协作组开展的针对复发性室管膜瘤患者采用单药和多药化疗的I期、II期和III期临床试验。此外，还将讨论与新型医学肿瘤治疗相关的未来方向。
