Broll R, Eckmann C, Kujath P, Bruch H P
Chirurgische Forschung, Medizinische Universität zu Lübeck.
Chirurg. 1998 Aug;69(8):806-12. doi: 10.1007/s001040050494.
Since the mid-1980s increasing numbers of severe group A streptococcal infections (Streptococcus pyogenes) have been reported worldwide. Younger, healthy patients after minor local trauma are most commonly afflicted. The infection is characterized by a rapid course with shock, sepsis, multiorgan failure, soft-tissue infection and a high mortality rate. This special disease has been termed "streptococcal toxic shock-like syndrome". The M-proteins, especially types 1 and 3, and the streptococcal pyrogenic exotoxin A (speA) might play an important role in the pathogenesis of the infection. High dose therapy with antibiotics, monitoring in the intensive care unit and early, aggressive and often multiple debridement of necrotic soft tissue are necessary to save the patient's life.
自20世纪80年代中期以来，全球范围内报告的严重A组链球菌感染（化脓性链球菌）病例越来越多。最常受影响的是遭受轻微局部创伤的较年轻健康患者。该感染的特点是病程迅速，伴有休克、败血症、多器官功能衰竭、软组织感染且死亡率高。这种特殊疾病被称为“链球菌中毒性休克样综合征”。M蛋白，尤其是1型和3型，以及链球菌致热外毒素A（speA）可能在感染的发病机制中起重要作用。为挽救患者生命，需要使用抗生素进行高剂量治疗、在重症监护病房进行监测以及对坏死软组织进行早期、积极且 often multiple清创。 （注：这里“often multiple”表述有点奇怪，可能原文有误，推测可能是“often multiple times”之类的，但按要求未修改原文直接翻译）
