Vuilleumier H, Halkic N
Department of Surgery, University Hospital, CHUV, Lausanne, Switzerland.
Swiss Surg. 2001;7(1):25-7. doi: 10.1024/1023-9332.7.1.25.
Group A streptococcus (GAS) or Streptococcus pyogenes cause a variety of life-threatening infectious complications including necrotizing fasciitis, purpura fulminans and streptococcal toxic shock syndrome (STSS). Exotoxins that act as superantigens are felt to be responsible for STSS. These exotoxins are highly destructive to skin, muscle and soft tissue. This syndrome has a rapid and fulminant course with frequently fatal outcome. GAS remains sensitive to penicillin but in serious infection a combination of clindamycin and ceftriaxone or meropenemum is recommended. Several studies have shown that mortality was dramatically reduced in STSS patients treated with immunoglobulin G given intravenously (IVIG). Early recognition of this most rapidly progressive infection and prompt operative debridement are required for successful management. This report presents a female patient at two month post-partum with a peritonitis and multi-organ failure.
A组链球菌(GAS)或化脓性链球菌可引起多种危及生命的感染并发症,包括坏死性筋膜炎、暴发性紫癜和链球菌中毒性休克综合征(STSS)。被认为作为超抗原起作用的外毒素是STSS的病因。这些外毒素对皮肤、肌肉和软组织具有高度破坏性。该综合征病程迅速且凶险,结局往往致命。GAS对青霉素仍敏感,但在严重感染时,推荐联合使用克林霉素和头孢曲松或美罗培南。多项研究表明,静脉注射免疫球蛋白G(IVIG)治疗的STSS患者死亡率显著降低。成功治疗需要早期识别这种进展最为迅速的感染并及时进行手术清创。本报告介绍了一名产后两个月出现腹膜炎和多器官功能衰竭的女性患者。