Toyama H, Lio M, Lisaka J, Chiba K, Yamada H, Matsui K, Hoshi Y, Fuse M
J Nucl Med. 1976 Nov;17(11):953-8.
Functional gamma imaging, in color, was established for regional cerebral blood flow (rCBF) using 133Xe. During 10 min after intracarotid injection of 133Xe in saline, 60 picture frames of the 133Xe clearance curve for the entire hemisphere were obtained. After nine-point smoothing, the rCBF for each of the 4,096 picture elements was calculated by two methods: the half-time method and the height-over-area method. Both the 133Xe clearance half-times and the calculated CBF values were displayed, using 13 steps of color, as functional CBF images of the brain. Images of peak count and total count were also displayed on the same frame of the color television. Forty-six studies, performed on 37 patients with various cerebral disorders, were divided into two types: diffuse and focal. In the diffuse type, a decrease in CBF was noted in cases of normal-pressure hydrocephalus; successful ventriculoperitoneal shunt operations were followed by recovery of CBF. Occlusion of the middle cerebral artery showed up as a wedge-shaped area of decreased CBF, even when the conventional brain scan looked normal. Increased perfusion to a tumor was frequently associated with decreased CBF in the rest of the lateral hemisphere; such a decrease could be improved by surgical removal of the tumor.
利用133Xe建立了彩色功能性γ成像技术，用于测量局部脑血流量（rCBF）。在经颈内动脉向盐水中注入133Xe后的10分钟内，获取了整个半球133Xe清除曲线的60个图像帧。经过九点平滑处理后，通过两种方法计算了4096个图像元素中每个元素的rCBF：半衰期法和高宽面积法。133Xe清除半衰期和计算出的CBF值均以13种颜色显示，作为大脑的功能性CBF图像。峰值计数和总计数的图像也显示在彩色电视机的同一帧上。对37例患有各种脑部疾病的患者进行的46项研究分为两种类型：弥漫性和局灶性。在弥漫性类型中，正常压力脑积水患者的CBF降低；成功进行脑室腹腔分流手术后，CBF恢复。大脑中动脉闭塞表现为CBF降低的楔形区域，即使传统脑扫描看起来正常。肿瘤灌注增加通常与外侧半球其余部分的CBF降低有关；通过手术切除肿瘤可以改善这种降低。
