Spiegel D, Wetzel W, Birngruber R
Klinik und Poliklinik für Augenheilkunde, Universität Regensburg.
Ophthalmologe. 1998 Aug;95(8):537-41. doi: 10.1007/s003470050312.
This study was conducted to compare the efficacy of the Er-YAG laser sclerostomy ab externo versus trabeculectomy in the treatment of primary open-angle glaucoma.
Twelve patients with POAG underwent ab externo laser sclerostomy using an Er-YAG laser (Sklerostom 2.9; lambda = 2940 nm, t = 200 microseconds, 2 Hz, 400 microns, 15 mJ). Only local medication was used, and there were no risk factors for failure. As a control group 12 patients out of 248 standardized trabeculectomies were matched in terms of age, sex, diagnosis and local medications. No antimetabolites were used in either group.
After a follow-up of 9 months in the sclerostomy group 53%; (7/12; P = 0.03) showed a patent fistula in comparison of 100% in the trabeculectomy group. There was a significantly lower mean IOP during the first postsurgical week in the group of sclerostomies (3.6 +/- 1.5 mmHg versus 7.5 +/- 2.7 mmHg; P = 0.0001) with a higher incidence of choroidal detachments (9/12 versus 2/12; P = 0.004). The choroidal detachments lasted longer in the sclerostomy group (3.5 months versus 0.3 months; P = 0.014). Iris incarcerations were found only in sclerostomies (7/12; P = 0.05).
Based on these findings, Er-YAG laser sclerostomy prooved to be less effective than trabeculectomy in the treatment of glaucoma patients. Er-YAG laser sclerostomies were associated with a higher incidence of postsurgical complications such as hypotony, choroidal detachments and iris incarcerations. At this point Er-YAG laser sclerostomy is not superior to conventional trabeculectomy.
本研究旨在比较经外路铒激光巩膜造瘘术与小梁切除术治疗原发性开角型青光眼的疗效。
12例原发性开角型青光眼患者接受了铒激光经外路巩膜造瘘术(Sklerostom 2.9;波长=2940nm,脉宽=200微秒,频率=2Hz,光斑直径=400微米,能量=15mJ)。仅使用局部药物治疗,且不存在手术失败的危险因素。作为对照组,从248例标准化小梁切除术中选取12例患者,在年龄、性别、诊断和局部用药方面进行匹配。两组均未使用抗代谢药物。
巩膜造瘘术组随访9个月后,53%(7/12;P=0.03)的患者显示瘘管通畅,而小梁切除术组这一比例为100%。巩膜造瘘术组术后第一周的平均眼压显著低于小梁切除术组(3.6±1.5mmHg对7.5±2.7mmHg;P=0.0),脉络膜脱离的发生率更高(9/12对2/12;P=0.004)。巩膜造瘘术组脉络膜脱离持续时间更长(3.5个月对0.3个月;P=0.014)。虹膜嵌顿仅在巩膜造瘘术组中发现(7/12;P=0.05)。
基于这些发现,铒激光巩膜造瘘术在治疗青光眼患者方面被证明不如小梁切除术有效。铒激光巩膜造瘘术与术后并发症如低眼压、脉络膜脱离和虹膜嵌顿的发生率较高有关。目前,铒激光巩膜造瘘术并不优于传统小梁切除术。