Wada Y, Nanbu Y, Jiang Z Y, Koshino Y, Hashimoto T
Department of Neuropsychiatry, Kanazawa University School of Medicine, Japan.
Clin Electroencephalogr. 1998 Oct;29(4):170-6. doi: 10.1177/155005949802900408.
We assessed functional relationships between hemispheres by calculating interhemispheric EEG coherence at rest and during photic stimulation in 18 never-medicated patients with paranoid schizophrenia and 30 control subjects. Although no significant group differences were found in the resting EEG, the schizophrenic patients had significantly higher coherence on EEGs recorded during photic stimulation, compared to the control subjects. In this study, we also examined the changes in interhemispheric coherence from rest to the stimulus condition (i.e., stimulation-related coherence reactivity); the patients were found to show significantly greater coherence reactivity to photic stimulation. These findings provide further evidence that schizophrenic patients have a higher degree of interhemispheric functional connectivity and thus have less lateralized cerebral organization than normal subjects. Our results also suggest that schizophrenic patients have excessive functional reorganization between hemispheres in association with photic stimulation.
我们通过计算18名未接受过药物治疗的偏执型精神分裂症患者和30名对照受试者在静息状态和光刺激期间的半球间脑电图连贯性，评估了半球之间的功能关系。虽然在静息脑电图中未发现显著的组间差异，但与对照受试者相比，精神分裂症患者在光刺激期间记录的脑电图上具有显著更高的连贯性。在本研究中，我们还检查了从静息状态到刺激状态半球间连贯性的变化（即与刺激相关的连贯性反应性）；发现患者对光刺激表现出显著更大的连贯性反应性。这些发现进一步证明，精神分裂症患者具有更高程度的半球间功能连接，因此与正常受试者相比，其大脑组织的偏侧化程度更低。我们的结果还表明，精神分裂症患者在光刺激相关的情况下，半球之间存在过度的功能重组。
