Kikuchi M, Wada Y, Koshino Y, Nanbu Y, Hashimoto T
Department of Neuropsychiatry, Kanazawa University School of Medicine, Japan.
Clin Electroencephalogr. 2000 Apr;31(2):109-15. doi: 10.1177/155005940003100210.
The present study of coherence analysis, in 16 healthy male volunteers, aged 24-31 years, showed that the administration of 0.25 mg of scopolamine significantly reduced interhemispheric coherence in the delta and beta-1 bands in the resting state. Scopolamine also caused a significant increase both in EEG coherence during PS and in PS-related coherence reactivity in the beta band. In addition, this compound significantly reduced total WMS scores. These findings suggest that, in addition to causing cognitive impairments, central cholinergic dysfunction can alter interhemispheric functional connectivity under both nonstimulus and stimulus conditions.
本研究对16名年龄在24至31岁之间的健康男性志愿者进行了相干分析，结果显示，给予0.25毫克东莨菪碱后，静息状态下δ波和β1波频段的半球间相干性显著降低。东莨菪碱还导致快速眼动睡眠（PS）期间脑电图相干性以及β波频段中与PS相关的相干反应性显著增加。此外，该化合物显著降低了韦氏记忆量表（WMS）总分。这些发现表明，除了导致认知障碍外，中枢胆碱能功能障碍在非刺激和刺激条件下均可改变半球间功能连接。
