Mochizuki Y, Oishi M, Hayakawa Y, Matsuzaki M, Takasu T
Department of Neurology, Nihon University School of Medicine, Tokyo, Japan.
Clin Electroencephalogr. 1998 Oct;29(4):194-6. doi: 10.1177/155005949802900413.
P300 event-related potentials were investigated in 24 cases of non-insulin-dependent (Type II) diabetes mellitus (NIDDM) without apparent central nervous system (CNS) symptoms and without cerebrovascular diseases on head magnetic resonance imaging, and in 16 age-matched healthy control subjects. N200 and P300 latencies were significantly prolonged and N200 and P300 amplitudes were significantly smaller in the NIDDM group than in the healthy control group. P300 latency was significantly shorter after the treatment than before. N200 and P300 waves have been recognized as useful indicators of cognitive function. The present study suggests that cognitive function is impaired in NIDDM patients and may improve with treatment of hyperglycemia.
对24例无明显中枢神经系统（CNS）症状且头部磁共振成像未显示脑血管疾病的非胰岛素依赖型（II型）糖尿病（NIDDM）患者以及16名年龄匹配的健康对照者进行了P300事件相关电位研究。NIDDM组的N200和P300潜伏期显著延长，N200和P300波幅显著小于健康对照组。治疗后P300潜伏期明显短于治疗前。N200和P300波已被认为是认知功能的有用指标。本研究表明，NIDDM患者存在认知功能损害，且高血糖治疗后认知功能可能改善。
