Anandhalakshmi Swaminathan, Rajkumar Ramanathan, Arulmurugan Karuppannan, Kumar Janardanan, Thirunavukarasu Manickam
Department of Physiology, All India Institute of Medical Sciences, Kalyani, West Bengal, India.
Department of Psychiatry, SRM Medical College, Kattangulathur, Chennai, India.
Ann Neurosci. 2020 Jul;27(3-4):98-103. doi: 10.1177/0972753120966824. Epub 2020 Nov 6.
Diabetes mellitus is the most prevailing metabolic disease. It causes structural and functional alterations in several organs, including the central nervous system. Altered glucose metabolism, atherosclerosis, and inflammation of blood vessels are seen in diabetes. This may lead to neuronal degeneration and decline in cognition. Event-related potential P300 can detect cognitive decline before the emergence of obvious neurological manifestations.
The aim of this study is to assess and compare the P300 latencies in subjects with type 2 diabetes mellitus and in nondiabetic subjects and to determine the influence of type 2 diabetes mellitus on cognitive functions.
In this study our sample size was 248 subjects, with type 2 diabetes mellitus patients ( = 124) and healthy controls ( = 124) between the age group of 31 and 60 years. This cross-sectional comparative study was conducted at SRM Medical College Hospital and Research Centre. The subjects were evaluated by a structured interview and they were assessed with a general health questionnaire to rule out any subpsychiatric illness. Fasting and postprandial blood glucose, HbA1c level, lipid profile, and creatinine were estimated. P300 amplitude and peak latencies were recorded using the standard auditory oddball paradigm.
The latencies of P300 were significantly increased and the amplitude of P300 was significantly reduced in the diabetic group when compared to the control group ( < .001). P300 latency has a positive correlation with the HbA1c levels ( = 0.136) and the duration of diabetes ( = 0.231).
Prolongation of P300 latencies and the decreased amplitude in diabetic subjects may suggest the existence of a cognitive decline in individuals with type 2 diabetes compared to healthy individuals.
糖尿病是最常见的代谢性疾病。它会导致包括中枢神经系统在内的多个器官发生结构和功能改变。糖尿病患者会出现葡萄糖代谢改变、动脉粥样硬化和血管炎症。这可能导致神经元变性和认知能力下降。事件相关电位P300可以在明显的神经学表现出现之前检测到认知能力下降。
本研究旨在评估和比较2型糖尿病患者与非糖尿病患者的P300潜伏期，并确定2型糖尿病对认知功能的影响。
本研究样本量为248名受试者，年龄在31至60岁之间，其中2型糖尿病患者124名，健康对照者124名。这项横断面比较研究在SRM医学院医院及研究中心进行。通过结构化访谈对受试者进行评估，并使用一般健康问卷对他们进行评估，以排除任何亚精神疾病。测定空腹和餐后血糖、糖化血红蛋白水平、血脂谱和肌酐。使用标准听觉oddball范式记录P300波幅和峰潜伏期。
与对照组相比，糖尿病组的P300潜伏期显著延长，P300波幅显著降低（P<0.001）。P300潜伏期与糖化血红蛋白水平（r = 0.136）和糖尿病病程（r = 0.231）呈正相关。
与健康个体相比，糖尿病患者P300潜伏期延长和波幅降低可能提示2型糖尿病患者存在认知能力下降。
