Voronina T A, Seredenin S B
Laboratory of Psychopharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
Eksp Klin Farmakol. 1998 Jul-Aug;61(4):3-9.
Recent studies in the field of molecular neurochemistry have demonstrated new mechanisms of regulation of the processes of training and memory, and on the basis of this new nootropic agents have been created. This work analyses in detail the most promising directions of research into the development of new nootropics acting on the deficiencies of synaptic transmission (cholinergic, glutamatergic. GAMA-ergic), free-radical affections, and peptidergic processes. Chemical heterogeneity, the wide variety of effects, and the difference in the mechanisms of action of the family of nootropics creates essential difficulties in the definition, classification, and determination of the mechanism of the nootropic effect proper, which is a frequent cause of the disagreement between the experimental and clinical data. Discussion of these problems is the subject of the present article.
分子神经化学领域的最新研究揭示了训练和记忆过程调节的新机制，并在此基础上研发出了新型益智药。本文详细分析了针对突触传递缺陷（胆碱能、谷氨酸能、γ-氨基丁酸能）、自由基影响和肽能过程开发新型益智药最具前景的研究方向。益智药家族的化学异质性、广泛的作用效果以及作用机制的差异，给正确定义、分类和确定益智作用机制带来了极大困难，这也是实验数据与临床数据不一致的常见原因。本文将对这些问题展开讨论。
