White J C, Adam B A, Lau K S, Horne R W, Parkhouse R M
J Pathol. 1976 Sep;120(1):25-33. doi: 10.1002/path.1711200104.
Recurrent gangrenous leg ulcers were associated with a monoclonal IgGk cryoglobulinaemia, though without overt myeloma. Cryoprecipitation of the serum in vitro gave a reversible gel with microtubular structure, built from the monomer and with a high degree of order. The same structure was found distending the superficial vessels of the ulcer biopsy, as well as extravascularly. There was no vasculitis, and luminal obstruction appeared responsible for the ulceration. Microtubular structures occur in nature among diverse proteins and viruses. The protein studied here is similar to a reported instance of myeloma cryo-IgGk.
复发性坏疽性腿部溃疡与单克隆IgGκ冷球蛋白血症相关，尽管没有明显的骨髓瘤。血清在体外进行冷沉淀可产生一种具有微管结构的可逆凝胶，由单体构成且具有高度的有序性。在溃疡活检的浅表血管以及血管外也发现了同样的结构。不存在血管炎，管腔阻塞似乎是溃疡形成的原因。微管结构在自然界中存在于多种蛋白质和病毒中。此处研究的蛋白质类似于报道的一例骨髓瘤冷球蛋白IgGκ。
