Powell F C, Schroeter A L, Su W P, Perry H O
Q J Med. 1985 May;55(217):173-86.
The clinical, histologic, and immunofluorescent findings in 86 cases of pyoderma gangrenosum seen at the Mayo Clinic between 1970 and 1983 were reviewed. Males and females were affected in equal numbers. The most frequent site of lesions was the leg. Sixty-seven patients (78 per cent) had associated systemic disease, with arthritis and inflammatory bowel disease being commonest. Cutaneous histopathologic changes varied with the site of biopsy. Lymphocytic vasculitis was predominant in the zone of erythema peripheral to the area of ulceration, while neutrophilic infiltrate and abscess formation were more prominent centrally. In most cases studied, direct immunofluorescence showed immunoglobulins and complement deposited in and around superficial and deep dermal vessels.
对1970年至1983年间在梅奥诊所就诊的86例坏疽性脓皮病患者的临床、组织学和免疫荧光检查结果进行了回顾。男性和女性受影响的人数相等。最常见的病变部位是腿部。67例患者（78%）伴有全身性疾病，其中关节炎和炎症性肠病最为常见。皮肤组织病理学变化因活检部位而异。淋巴细胞性血管炎在溃疡周围的红斑区域占主导地位，而中性粒细胞浸润和脓肿形成在中央更为突出。在大多数研究病例中，直接免疫荧光显示免疫球蛋白和补体沉积在浅表和深部真皮血管内及周围。
