Brill' G E, Zakharova E I
Central Research Laboratory, Saratov, Russia.
Eksp Klin Farmakol. 1998 Jul-Aug;61(4):54-6.
The effect of dimethyl sulfoxide (dimexid, DMSO) on the lymph microvessels of the rat mesentery was studied by vital biomicroscopy. It was found that 30% DMSO increases the tonus of intact lymph microvessels and stimulates their phase contractions. Action of the agent for more than 15 min leads to the development of lymphostasis. DMSO has a pronounced corrective effect on disorders of lymph microcirculation caused by the staphylococcal toxin. It removes the main lymphopathogenic effects of the poison and normalizes the drainage function of the lymphangions. The correcting effect of DMSO on lymph circulation is attended with attenuation of the fatal effect of the toxin.
采用活体生物显微镜技术研究了二甲基亚砜（万能溶媒，DMSO）对大鼠肠系膜淋巴微血管的影响。结果发现，30%的二甲基亚砜可增强完整淋巴微血管的紧张度并刺激其阶段性收缩。该制剂作用超过15分钟会导致淋巴淤积。二甲基亚砜对由葡萄球菌毒素引起的淋巴微循环障碍具有显著的纠正作用。它可消除毒素的主要致淋巴病效应并使淋巴管的引流功能正常化。二甲基亚砜对淋巴循环的纠正作用伴随着毒素致命效应的减弱。
