Uteshev D B, Sergeev A V, Uteshev B S
Department of Pharmacology, Russian State Medical University, Moscow, Russia.
Eksp Klin Farmakol. 1998 Jul-Aug;61(4):57-65.
The article deals with the latest achievements in the interpretation of the mechanism of programmed cell death (apoptosis). The effect of drugs on the different stages of the apoptotic signal conduction is analysed. The earliest prospects of creating apoptosis regulating agents are planned. It is suggested that tests for apoptosis should be included in the list of obligatory ones in the preclinical studies of new biologically active compounds.
本文论述了程序性细胞死亡（凋亡）机制阐释方面的最新成果。分析了药物对凋亡信号传导不同阶段的影响。规划了研发凋亡调节药物的最新前景。建议在新生物活性化合物临床前研究的必做检测项目清单中纳入凋亡检测。
