Wertz I E, Hanley M R
Department of Biological Chemistry, School of Medicine, University of California at Davis 95616, USA.
Trends Biochem Sci. 1996 Oct;21(10):359-64.
The experimental study and manipulation of programmed cell death has been greatly assisted by the identification of genetic and pharmacological tools that can either induce or block cell lethality. This review discusses new insights into the molecular sensing of perturbations induced by such tools, as well as the possible consequences of this detection in determining cell survival.
能够诱导或阻断细胞致死性的遗传和药理学工具的发现，极大地推动了对程序性细胞死亡的实验研究和操作。本综述讨论了对此类工具诱导的扰动进行分子感知的新见解，以及这种检测在决定细胞存活方面可能产生的后果。
