Kolchanov N A, Ponomarenko M P, Kel A E, Frolov A S, Kolpakov F A, Goryachkovsky T N, Kel O V, Ananko E A, Ignatieva E V, Podkolodnaya O A, Babenko V N, Stepanenko I L, Romashchenko A G, Merkulova T I, Vorobiev D G, Lavryushev S V, Kochetov A V, Kolesov G B, Solovyev V V, Milanesi L, Podkolodny N L, Wingender E, Heinemeyer T
Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Proc Int Conf Intell Syst Mol Biol. 1998;6:95-104.
GeneExpress system has been designed to integrate description, analysis, and recognition of eukaryotic regulatory sequences. The system includes 5 basic units: (1) GeneNet contains an object-oriented database for accumulation of data on gene networks and signal transduction pathways and a Java-based viewer that allows an exploration and visualization of the GeneNet information; (2) Transcription Regulation combines the database on transcription regulatory regions of eukaryotic genes (TRRD) and TRRD Viewer; (3) Transcription Factor Binding Site Recognition contains a compilation of transcription factor binding sites (TFBSC) and programs for their analysis and recognition; (4) mRNA Translation is designed for analysis of structural and contextual features of mRNA 5'UTRs and prediction of their translation efficiency; and (5) ACTIVITY is the module for analysis and site activity prediction of a given nucleotide sequence. Integration of the databases in the GeneExpress is based on the Sequence Retrieval System (SRS) created in the European Bioinformatics Institute.
基因表达系统旨在整合真核生物调控序列的描述、分析和识别。该系统包括5个基本单元：（1）基因网络（GeneNet）包含一个面向对象的数据库，用于积累基因网络和信号转导途径的数据，以及一个基于Java的查看器，可用于探索和可视化基因网络信息；（2）转录调控（Transcription Regulation）结合了真核基因转录调控区域数据库（TRRD）和TRRD查看器；（3）转录因子结合位点识别（Transcription Factor Binding Site Recognition）包含转录因子结合位点汇编（TFBSC）及其分析和识别程序；（4）mRNA翻译（mRNA Translation）用于分析mRNA 5'非翻译区的结构和上下文特征，并预测其翻译效率；（5）活性（ACTIVITY）是用于分析给定核苷酸序列并预测其位点活性的模块。基因表达系统中数据库的整合基于欧洲生物信息学研究所创建的序列检索系统（SRS）。
