Burtseva E I, Slepushkin A N, Beliaev A L, Kolobukhina L V, Merkulova L N, Boltenko V V, Stepnova A I, Beregovskiĭ N A, Rudenko L G
Ivanovsky Research Institute of Virology, Moscow, Russia.
Zh Mikrobiol Epidemiol Immunobiol. 1998 Jul-Aug(4):40-5.
To improve the vaccinal prophylaxis of influenza, the comparative study of live trivalent influenza allantoic vaccine, dried, for adults, produced by the Irkutsk Enterprise for Immunological Preparations (Russia), and inactivated trivalent influenza split vaccine, obtained from Wyeth-Ayerst Company (USA), as well as schedules of their combined use for the vaccination of elderly persons, was carried out. The examination of 600 subjects revealed that the vaccines were well tolerated; the combined use of these two vaccines, as well as the use of the inactivated influenza vaccine (IIV) alone, ensured high immunogenic activity (60.0-80.0% of seroconversions). The live influenza vaccine (LIV) stimulated the production of specific antibodies only in 19.0-35.0% of the vaccinees; most of these vaccinees exhibited positive reaction only to one of the vaccine strains. Following the injection of LIV, the level of postvaccinal immunity was retained for at least 6 months. In the vaccinees receiving both vaccines the tendency towards a decrease in mean geometric titer values was less pronounced (0.2-0.4 log2) than in those receiving only IIV (0.5-0.7 log2). At the period of the rise of influenza morbidity, the contamination rate in the vaccinees with the positive postvaccinal dynamics of antibodies was low (26.0%). The indices of effectiveness were 3.8 for combined vaccination, 3.5 for IIV and 2.6 for LIV. The schedule of vaccination with IIV with the possible revaccination LIV 3-4 weeks later was recommended.
为提高流感疫苗预防效果，对俄罗斯伊尔库茨克免疫制剂企业生产的冻干成人用三价流感鸡胚尿囊活疫苗、美国惠氏-艾尔斯特公司生产的三价流感裂解灭活疫苗以及二者联合用于老年人接种的方案进行了对比研究。对600名受试者的检查表明，这些疫苗耐受性良好；两种疫苗联合使用以及单独使用灭活流感疫苗（IIV）均能确保高免疫原活性（血清转化率为60.0 - 80.0%）。活流感疫苗（LIV）仅在19.0 - 35.0%的接种者中刺激产生特异性抗体；这些接种者中的大多数仅对一种疫苗株呈现阳性反应。注射LIV后，疫苗后免疫水平至少维持6个月。在同时接种两种疫苗的接种者中，平均几何滴度值下降的趋势（0.2 - 0.4 log2）比仅接种IIV的接种者（0.5 - 0.7 log2）不那么明显。在流感发病率上升期间，抗体疫苗后动态呈阳性的接种者的感染率较低（26.0%）。联合接种的有效性指数为3.8，IIV为3.5，LIV为2.6。推荐采用先接种IIV，3 - 4周后可能再接种LIV的接种方案。
