Casiglia E, Palatini P
Department of Clinical and Experimental Medicine, Clinica Medica 1, University of Padova, Italy.
J Hum Hypertens. 1998 Sep;12(9):575-81. doi: 10.1038/sj.jhh.1000668.
Although a number of risk factors for cardiovascular morbidity and mortality have been identified in young and middle-aged adults, their prevalence and importance are less known in the elderly. Elderly people have a risk profile different from that of younger subjects, but representative data on risk factors for cardiovascular disease in the elderly are difficult to find in the literature. Some typical 'major' risk factors, like blood pressure (BP), total cholesterol or left ventricular hypertrophy, do not have a clear predictive role for cardiovascular mortality in the elderly, especially in the extreme ages, while risk indicators usually labelled as 'minor' (serum uric acid, ventilatory function or proteinuria), do have a strong predictive value in these individuals. This must be taken into account when evaluating the cumulative risk of the elderly, in order to avoid overtreatment of subjects with mildly elevated BP or cholesterol.
虽然在中青年人群中已确定了一些心血管疾病发病和死亡的风险因素,但在老年人中其患病率和重要性却鲜为人知。老年人的风险特征与年轻人不同,但文献中很难找到关于老年人心血管疾病风险因素的代表性数据。一些典型的“主要”风险因素,如血压(BP)、总胆固醇或左心室肥厚,对老年人的心血管死亡率并没有明确的预测作用,尤其是在高龄人群中,而通常被标记为“次要”的风险指标(血清尿酸、通气功能或蛋白尿),在这些个体中却具有很强的预测价值。在评估老年人的累积风险时必须考虑到这一点,以避免对血压或胆固醇轻度升高的患者进行过度治疗。