Tarlin H, Hudson M, Sahn M
J Pharm Sci. 1976 Oct;65(10):1463-5. doi: 10.1002/jps.2600651012.
A rapid automated method for determining epinephrine in lidocaine hydrochloride injection is presented. The method is an adaptation of the official USP XIX fluorometric procedure and yields equivalent results. The linearity, accuracy, precision, excipient/background effect, and carryover characteristics of the automated system are described. A recovery study indicated that intact epinephrine is measured accurately in the presence of its degradation products. Analysis of several commercial preparations is reported.
本文介绍了一种快速自动化方法，用于测定盐酸利多卡因注射液中的肾上腺素。该方法是对美国药典第十九版荧光测定法的改进，结果相当。描述了自动化系统的线性、准确性、精密度、辅料/背景效应及残留特性。一项回收率研究表明，在肾上腺素降解产物存在的情况下，仍能准确测定完整的肾上腺素。报告了对几种市售制剂的分析情况。
