Weber D J
J Pharm Sci. 1976 Oct;65(10):1502-5. doi: 10.1002/jps.2600651021.
A high-pressure liquid chromatographic (HPLC) analysis of tolbutamide in serum is described. The assay requires only 1 ml of serum and is capable of measuring as little as 2 mug of tolbutamide. The metabolites of tolbutamide do not interfere in the assay. Human serum samples, taken after a 1-g oral dose of tolbutamide, were analyzed by the HPLC and an existing GLC procedure, and the results are compared.
本文描述了血清中甲苯磺丁脲的高压液相色谱（HPLC）分析方法。该测定仅需1毫升血清，能够检测低至2微克的甲苯磺丁脲。甲苯磺丁脲的代谢产物不干扰该测定。对口服1克甲苯磺丁脲后采集的人血清样本进行了HPLC分析，并与现有的气相色谱（GLC）方法进行了比较。
