Niazi S
J Pharm Sci. 1976 Oct;65(10):1539-40.
A comparison was made between instantaneous input assumption and short-term zero-order infusion for 1 and 2 min for several drugs showing fast distribution to the tissue compartments. The errors ranged from 9 to 40% for the volume of the central compartment, from 0.7 to 11% for the volume of distribution following pseudo-distribution equilibrium, and from 11 to 34% for the volume of distribution change at the end of the 2-min infusion period. Significant errors in the tissue levels also were observed. It was suggested that all intravenous administrations be considered as short-term zero-order inputs.
对几种快速分布到组织隔室的药物，就瞬时输入假设与1分钟和2分钟的短期零级输注进行了比较。中央隔室体积的误差范围为9%至40%，伪分布平衡后的分布体积误差范围为0.7%至11%，2分钟输注期结束时分布体积变化的误差范围为11%至34%。在组织水平上也观察到了显著误差。有人建议，所有静脉给药都应视为短期零级输入。
