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用差示分光光度法对药物剂型中的茶碱进行定量测定。

Quantitative determination of theophylline in pharmaceutical dosage forms by differential spectrophotometry.

作者信息

Chae Y S, Shelver W H

出版信息

J Pharm Sci. 1976 Aug;65(8):1178-81. doi: 10.1002/jps.2600650812.

DOI:10.1002/jps.2600650812
PMID:978437
Abstract

Theophylline was determined with good precision in tablets and capsules by differential spectrophotometry. Xanthines such as caffeine and theobromine did not interfere providing the total xanthine concentration was kept below 100 mug/ml. At a higher total xanthine concentration, nonlinearity occurred, presumably due to complex formation. This interference could be minimized by proper selection of the analytical wavelength.

摘要

采用差示分光光度法可精确测定片剂和胶囊中的茶碱。只要黄嘌呤总浓度保持在100μg/ml以下，咖啡因和可可碱等黄嘌呤就不会产生干扰。在较高的黄嘌呤总浓度下，会出现非线性现象，这可能是由于形成了络合物。通过适当选择分析波长，可将这种干扰降至最低。

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