Ochsner A B, Belloto R J, Sokoloski T D
J Pharm Sci. 1985 Feb;74(2):132-5. doi: 10.1002/jps.2600740206.
Mixture response-surface methodology can be used as a technique to predict solubility in mixed solvent systems. The present report shows that if the intent is to predict solubility in nonideal solutions, mixture response-surface methodology is a better technique than one which assumes a particular mechanism to hold true. This is demonstrated by comparing the predictive ability of the mixture response-surface model with that of an extended Hildebrand approach to nonideal solutions. The nonideal systems are those used by Martin and co-workers involving the solubility of theobromine, caffeine, and theophylline in dioxane-water mixtures.
混合响应面法可作为一种预测混合溶剂体系中溶解度的技术。本报告表明，如果目的是预测非理想溶液中的溶解度，那么混合响应面法比假定某一特定机制成立的方法是一种更好的技术。通过比较混合响应面模型与扩展的希尔德布兰德非理想溶液方法的预测能力，证明了这一点。非理想体系是马丁及其同事所使用的涉及可可碱、咖啡因和茶碱在二氧六环 - 水混合物中溶解度的体系。
