Pastori M, Pfander H, Boscoboinik D, Azzi A
Institute for Biochemistry and Molecular Biology, University of Bern, Bern, CH-3012, Switzerland.
Biochem Biophys Res Commun. 1998 Sep 29;250(3):582-5. doi: 10.1006/bbrc.1998.9351.
The effect of lycopene alone or in association with other antioxidants was studied on the growth of two different human prostate carcinoma cell lines (the androgen insensitive DU-145 and PC-3). It was found that lycopene alone was not a potent inhibitor of prostate carcinoma cell proliferation. However, the simultaneous addition of lycopene together with alpha-tocopherol, at physiological concentrations (less than 1 microM and 50 microM, respectively), resulted in a strong inhibitory effect of prostate carcinoma cell proliferation, which reached values close to 90 %. The effect of lycopene with alpha-tocopherol was synergistic and was not shared by beta-tocopherol, ascorbic acid and probucol.
研究了单独使用番茄红素或与其他抗氧化剂联合使用对两种不同的人前列腺癌细胞系（雄激素不敏感的DU - 145和PC - 3）生长的影响。结果发现，单独使用番茄红素并非前列腺癌细胞增殖的有效抑制剂。然而，在生理浓度（分别小于1微摩尔和50微摩尔）下，将番茄红素与α-生育酚同时添加，会对前列腺癌细胞增殖产生强烈的抑制作用，抑制率接近90%。番茄红素与α-生育酚的作用具有协同性，而β-生育酚、抗坏血酸和普罗布考则没有这种协同作用。
