P-糖蛋白外排泵：它是如何转运药物的？ - Suppr

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超能文献

The P-glycoprotein efflux pump: how does it transport drugs?

作者信息

Roepe P D

机构信息

Department of Chemistry & Lombardi Cancer Center, Georgetown University, Washington, DC 20057, USA.

出版信息

J Membr Biol. 1998 Nov 1;166(1):71-3. doi: 10.1007/s002329900448.

DOI:10.1007/s002329900448

PMID:9784587

Abstract

摘要

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Analysis of ion transport perturbations caused by hu MDR 1 protein overexpression.人多药耐药蛋白1（hu MDR 1）过表达引起的离子转运扰动分析。

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Are altered pHi and membrane potential in hu MDR 1 transfectants sufficient to cause MDR protein-mediated multidrug resistance?人多药耐药1转染细胞中改变的细胞内pH值和膜电位是否足以导致多药耐药蛋白介导的多药耐药？

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Effects of membrane potential versus pHi on the cellular retention of doxorubicin analyzed via a comparison between cystic fibrosis transmembrane conductance regulator (CFTR) and multidrug resistance (MDR) transfectants.

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