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The P-glycoprotein efflux pump: how does it transport drugs?

作者信息

Roepe P D

机构信息

Department of Chemistry & Lombardi Cancer Center, Georgetown University, Washington, DC 20057, USA.

出版信息

J Membr Biol. 1998 Nov 1;166(1):71-3. doi: 10.1007/s002329900448.

DOI:10.1007/s002329900448
PMID:9784587
Abstract
摘要

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The P-glycoprotein efflux pump: how does it transport drugs?P-糖蛋白外排泵：它是如何转运药物的？
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本文引用的文献

1
Human MDR 1 protein overexpression delays the apoptotic cascade in Chinese hamster ovary fibroblasts.人类多药耐药蛋白1（MDR 1）的过表达会延迟中国仓鼠卵巢成纤维细胞中的凋亡级联反应。
Biochemistry. 1997 Sep 16;36(37):11169-78. doi: 10.1021/bi9627830.
2
Analysis of ion transport perturbations caused by hu MDR 1 protein overexpression.人多药耐药蛋白1（hu MDR 1）过表达引起的离子转运扰动分析。
Biochemistry. 1997 Sep 16;36(37):11153-68. doi: 10.1021/bi970530g.
3
Altered pHi regulation in 3T3/CFTR clones and their chemotherapeutic drug-selected derivatives.
基于 Pgp 介导的多药耐药的生物物理和数学模型：理解 MDR 的“时空”维度。
Eur Biophys J. 2010 Jan;39(2):201-11. doi: 10.1007/s00249-009-0555-5. Epub 2009 Nov 4.
4
Effect of the modulation of the membrane lipid composition on the localization and function of P-glycoprotein in MDR1-MDCK cells.膜脂成分调节对多药耐药蛋白1-犬肾上皮细胞（MDR1-MDCK细胞）中P-糖蛋白定位和功能的影响
In Vitro Cell Dev Biol Anim. 2005 Jul-Aug;41(7):207-16. doi: 10.1290/0502016.1.
3T3/CFTR克隆及其化疗药物筛选衍生物中pHi调节的改变。
Am J Physiol. 1997 May;272(5 Pt 1):C1642-53. doi: 10.1152/ajpcell.1997.272.5.C1642.
4
Biophysical aspects of P-glycoprotein-mediated multidrug resistance.P-糖蛋白介导的多药耐药性的生物物理方面
Int Rev Cytol. 1997;171:121-65. doi: 10.1016/s0074-7696(08)62587-5.
5
Are altered pHi and membrane potential in hu MDR 1 transfectants sufficient to cause MDR protein-mediated multidrug resistance?人多药耐药1转染细胞中改变的细胞内pH值和膜电位是否足以导致多药耐药蛋白介导的多药耐药？
J Gen Physiol. 1996 Oct;108(4):295-313. doi: 10.1085/jgp.108.4.295.
6
Effects of membrane potential versus pHi on the cellular retention of doxorubicin analyzed via a comparison between cystic fibrosis transmembrane conductance regulator (CFTR) and multidrug resistance (MDR) transfectants.
Biochem Pharmacol. 1996 Oct 11;52(7):1081-95. doi: 10.1016/0006-2952(96)81736-9.
7
Dissociation of phospholamban regulation of cardiac sarcoplasmic reticulum Ca2+ATPase by quercetin.
J Biol Chem. 1996 Oct 4;271(40):24517-25. doi: 10.1074/jbc.271.40.24517.
8
Intracellular pH and the control of multidrug resistance.细胞内pH值与多药耐药性的控制
Proc Natl Acad Sci U S A. 1994 Feb 1;91(3):1128-32. doi: 10.1073/pnas.91.3.1128.
9
The TF1-ATPase and ATPase activities of assembled alpha 3 beta 3 gamma, alpha 3 beta 3 gamma delta, and alpha 3 beta 3 gamma epsilon complexes are stimulated by low and inhibited by high concentrations of rhodamine 6G whereas the dye only inhibits the alpha 3 beta 3, and alpha 3 beta 3 delta complexes.组装好的α3β3γ、α3β3γδ和α3β3γε复合物的TF1 - ATP酶和ATP酶活性在低浓度时受到若丹明6G的刺激，在高浓度时受到抑制，而该染料仅抑制α3β3和α3β3δ复合物。
J Bioenerg Biomembr. 1993 Dec;25(6):679-84. doi: 10.1007/BF00770254.
10
Transfection of mu MDR 1 inhibits Na(+)-independent Cl-/-HCO3 exchange in Chinese hamster ovary cells.转染鼠多药耐药基因1抑制中国仓鼠卵巢细胞中的非钠依赖型氯/碳酸氢根交换。
Biochemistry. 1994 Jun 14;33(23):7239-49. doi: 10.1021/bi00189a028.