Maurage C, Guesnet P, Pinault M, Rochette de Lempdes J, Durand G, Antoine J, Couet C
Equipe Associée, Université de Tours EA2103-INRA, Laboratoire de Nutrition et Securité Alimentaire, Jouy-en-Josas, France.
Biol Neonate. 1998 Dec;74(6):416-29. doi: 10.1159/000014063.
We studied the effect of docosahexaenoic acid (DHA) supplementation of infant formulas on fatty acid composition of blood phospholipids in term infants. Two fish oil supplemented formulas containing 0.45 wt% DHA and high (0.35%) or low (0.10%) eicosapentaenoic acid (EPA) were fed for 42 days and compared with a standard formula and breast milk. Infants fed supplemented formulas and breast milk had similar time-dependent changes for DHA from birth to day 42, i.e., slight decreases in plasma phospholipids and erythrocyte phosphatidylcholine and no change in erythrocyte phosphatidylethanolamine. Low-EPA formula prevented EPA accumulation but did not limit the significant decrease in arachidonic acid (AA) noted in infants fed high-EPA formula. These results suggest that term infant formulas should be supplemented with DHA-rich EPA, low fish oil and AA to achieve a fatty acid status in formula-fed infants similar to that of breast-fed infants.
我们研究了在婴儿配方奶粉中添加二十二碳六烯酸（DHA）对足月儿血液磷脂脂肪酸组成的影响。两种添加鱼油的配方奶粉，分别含有0.45 wt% DHA以及高含量（0.35%）或低含量（0.10%）的二十碳五烯酸（EPA），喂养42天，并与标准配方奶粉和母乳进行比较。喂养添加配方奶粉和母乳的婴儿从出生到第42天，DHA的时间依赖性变化相似，即血浆磷脂和红细胞磷脂酰胆碱略有下降，红细胞磷脂酰乙醇胺无变化。低EPA配方奶粉可防止EPA积累，但并未限制高EPA配方奶粉喂养的婴儿中花生四烯酸（AA）的显著下降。这些结果表明，足月儿配方奶粉应补充富含DHA的EPA、低鱼油和AA，以使配方奶粉喂养的婴儿达到与母乳喂养婴儿相似的脂肪酸状态。
