Manojkumar V, Padmakumaran Nair K G, Santhosh A, Deepadevi K V, Arun P, Lakshmi L R, Kurup P A
Department of Biological Sciences, Peninsula Polymers Limited, Trivandrum, India.
Vox Sang. 1998;75(2):139-44.
Significant amounts of di(2-ethylhexyl) phthlate (DEHP) leach into blood stored in DEHP-plasticized PVC bags. The aim of this study was to find out whether DEHP at these low levels has any effect on the concentration of vitamin E, an antioxidant which affords protection against free radical damage.
DEHP was administered in low doses (150-750 microg/100 g body weight) to rats intraperitoneally and the concentration of vitamin E in the liver and testes was measured. Concentration of vitamin E was also measured in blood stored in glass bottles in the presence and absence of DEHP and in blood stored in DEHP-plasticized PVC bags.
A decrease in the concentration of vitamin E was observed in all cases. Administration of vitamin E to rats and incorporation of vitamin E in the additive solution in the case of blood prevented this decrease.
DEHP even at very low doses caused a decrease in the concentration of vitamin E in liver and tests of rats given this substance. Blood stored in DEHP-plasticized bags also showed a decrease in the concentration of vitamin E.
大量邻苯二甲酸二（2-乙基己基）酯（DEHP）会渗入储存在用DEHP增塑的聚氯乙烯袋中的血液中。本研究的目的是确定这些低水平的DEHP是否会对维生素E的浓度产生影响，维生素E是一种抗氧化剂，可防止自由基损伤。
以低剂量（150 - 750微克/100克体重）腹腔注射DEHP给大鼠，并测量肝脏和睾丸中维生素E的浓度。还测量了在有和没有DEHP的情况下储存在玻璃瓶中的血液以及储存在用DEHP增塑的聚氯乙烯袋中的血液中维生素E的浓度。
在所有情况下均观察到维生素E浓度降低。给大鼠服用维生素E以及在血液的添加剂溶液中加入维生素E可防止这种降低。
即使是非常低剂量的DEHP也会导致给予该物质的大鼠肝脏和睾丸中维生素E浓度降低。储存在用DEHP增塑袋中的血液中维生素E浓度也出现降低。
