Chávez E, Zazueta C, Cuéllar A, Reyes-Vivas H, García N
Departamento de Bioquímica, Instituto Nacional de Cardiología, Ignacio Chávez, México, D.F., México.
Biochem Mol Biol Int. 1998 Sep;46(1):207-14. doi: 10.1080/15216549800203712.
This paper reports evidence that exposure of mitochondria to near-ultraviolet light inhibits electron transport, collapses the electric gradient, and increases non-specific membrane permeability to matrix solutes such as Ca2+. Membrane energization, as well as superoxide dismutase and catalase avoid membrane leakiness. Increased permeability correlates with a diminution in the titrated thiol groups. Plausibly the pore is formed through the formation of sulfhydryl bridges by the action of UV light-derived oxygen-centered free- radicals on membrane proteins.
线粒体暴露于近紫外线下会抑制电子传递、破坏电化学梯度，并增加对基质溶质（如Ca2+）的非特异性膜通透性。膜的能量化以及超氧化物歧化酶和过氧化氢酶可避免膜渗漏。通透性增加与滴定的巯基减少相关。推测该孔是由紫外线衍生的以氧为中心的自由基作用于膜蛋白形成巯基桥而形成的。
