Mansoura M K, Dawson D C
Department of Biomedical Engineering, University of Michigan Medical School, Ann Arbor 48109, USA.
Comput Biol Med. 1998 May;28(3):255-73. doi: 10.1016/s0010-4825(98)00006-7.
An interactive ion channel permeation tutorial was developed using a Microsoft Excel v5.0 spreadsheet to describe a two barrier, one site channel model by means of Eyring rate theory (ERT). The spreadsheet is inherently interactive so that the user receives immediate feedback about how changes in the energy barrier profile or ion concentrations affect current-voltage relations and single channel conductance. The spreadsheet model is easy to use, allows direct access to intermediate calculated values and all equations, contains graphical displays of parameters and lends itself to customization by a user having only a basic knowledge of spreadsheet operations.
利用微软Excel v5.0电子表格开发了一个交互式离子通道渗透教程，以借助艾林速率理论（ERT）描述双屏障、单位点通道模型。该电子表格具有内在的交互性，因此用户可立即得到关于能垒分布或离子浓度变化如何影响电流-电压关系和单通道电导的反馈。该电子表格模型易于使用，可直接获取中间计算值和所有方程，包含参数的图形显示，并且仅具备电子表格操作基础知识的用户即可对其进行定制。
