Matteri R L, Klir J J, Fink B N, Johnson R W
Animal Physiology Research Unit, United States Department of Agriculture, Columbia, MO 65211, USA.
Domest Anim Endocrinol. 1998 Sep;15(5):397-407. doi: 10.1016/s0739-7240(98)00024-1.
Cytokine responses to lipopolysaccharides in neuroendocrine tissues are age- and tissue-dependent in neonatal pigs. Developmental differences in serum and tissue-specific responses are not necessarily equivalent. Lower levels of cytokine gene expression in neuroendocrine tissues of early neonates potentially could influence neuroendocrine and immune responses to infection. The limited information on neuroendocrine-immune responses and interactions in neonatal farm animals presents significant challenges, as well as opportunities for new discoveries and improvements of livestock production.
新生仔猪神经内分泌组织中细胞因子对脂多糖的反应具有年龄和组织依赖性。血清和组织特异性反应的发育差异不一定相同。早期新生儿神经内分泌组织中细胞因子基因表达水平较低，可能会影响对感染的神经内分泌和免疫反应。关于新生农场动物神经内分泌-免疫反应及相互作用的信息有限，这既带来了重大挑战，也为新发现和改善畜牧生产提供了机遇。
